Bioactive Small Molecules
Medchemexpress LLC 6-chloro-1,2-benzisothiazol-3(2H)-one | 70-10-0 | MFCD00865021 | 98.5% | C7H4ClNOS | 10MG
Ticlatone (6-chloro-1,2-benzisothiazol-3(2H)-one) is a small-molecule antifungal research reagent used to study mycoses. It has molecular formula C7H4ClNOS and molecular weight 185.63 g/mol. Provided as a high-purity solid, it is intended for chemical and in vitro biological research applications.
- Antifungal activity useful for mycoses research.
- High purity suitable for analytical and biological assays.
- Defined molecular formula and molecular weight for characterization.
- Stable solid form for standard laboratory handling and storage.
- Known synonyms and identifiers facilitate database searching.
![Medchemexpress LLC Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl- | 1396814-79-1 | 98.5% | 335.47 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl- | 1396814-79-1 | 98.5% | 335.47 | 25 MG
VU0542270 is a selective vascular Kir6.1/SUR2B KATP channel inhibitor with an IC50 value of 100 nM. It has an IC50 > 30 μM for the other nine members of the Kir channel family. It can be used in the study of cardiovascular disease.
- Selective vascular Kir6.1/SUR2B KATP channel inhibitor.
- Can be used in the study of cardiovascular disease.
- High selectivity, with IC50 > 30 μM for other Kir channel family members.
Cayman Chemical Clodesnitazene (citrate), Purity: ≥98%, 5 mg
An analytical reference standard that is structurally similar to known opioids; intended for research and forensic applications
Medchemexpress LLC HY-10997S 5mg Medchemexpress, Ibrutinib D5 CAS:1553977-17-5 Purity:>98%
Medchemexpress, HY-10997S 5mg Ibrutinib D5 CAS:1553977-17-5 Ibrutinib D5 (PCI-32765 D5) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Gracillin | 19083-00-2 | 885.04 | 25 MG
Gracillin is a steroidal saponin extracted from plant roots with anti-tumor properties. It can induce cancer cell apoptosis and autophagy.
- Steroidal saponin.
- Exhibits anti-tumor properties.
- Induces cancer cell apoptosis and autophagy.
- Shows broad-spectrum inhibitory effects on cancer cell viability (e.g., A2780, A549, BXPC-3, Bel-7402, Capan-2, HCT-8, HL-60, HeLa, MCF7, PANC-1, SW1990 cells).
- Disrupts mitochondrial function by inhibiting ATP production, activating AMPK, and inhibiting oxygen consumption rate (OCR) in H460 and A549 cells.
- Induces ROS generation in H460, H1299, H226B, and A549 cells.
- Blocks cell cycle in G1 phase and induces apoptosis and autophagy in A549 cells.
- Inhibits tumor growth of xenograft tumors in lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors.
Cayman Chemical NMS-E973, Purity: ≥98%, CAS: 1253584-84-7, 10 mg
An HSP90 inhibitor (IC50 = 10 nM in a fluorescence polarization assay); decreases HER2 protein expression (IC50 = 110 nM) in BT474 breast cancer cells; inhibits the growth of a 16 cancer cell line panel (IC50s = 13-362 nM); reduces tumor growth by 74% in an A2780 mouse xenograft model at a dose of 60 mg/kg, i.v., per day for ten days; completely eradicates MOLM-13 acute myeloid leukemia tumors in a mouse xenograft model
Medchemexpress LLC Tegafur-Uracil | 74578-38-4 | 99.77% | 312.25 | 5 MG
Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. It inhibits thymidylate synthase and can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors.
- Effective oral chemotherapy drug based on fluoropyrimidine.
- Inhibits thymidylate synthase.
- Can be used with leucovorin (LV) and polysaccharide K (PSK) for solid tumor research.
- For research use only.
Medchemexpress LLC HY-B0185 500mg Medchemexpress, Lidocaine CAS:137-58-6 Purity:>98%
Medchemexpress, HY-B0185 500mg Lidocaine CAS:137-58-6 Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative commonly used to anesthetize. Lidocaine is a drug to treat ventricular arrhythmia and an effective tumor-inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC A-443654 552325-16-3 10mM (in 1mL DMSO)
A-443654 (CAS 552325-16-3) is a potent selective small molecule inhibitor targeting all three Akt isoforms by binding the ATP pocket and reversibly inhibiting kinase activity (Ki 160 pM) It shows strong selectivity for Akt over other kinases and suppresses downstream substrate phosphorylation including GSK3 FOXO3 TSC2 mTOR 4EBP-1 and S6 In cellular assays A-443654 inhibits Akt activity and induces apoptosis or cell cycle arrest across cancer models with reported EC50 values of 100 nM (MiaPaCa-2) and 0 63 M (CLL cells) In in vivo xenograft models it significantly reduces tumor growth either as monotherapy or in combination with rapamycin A-443654 is widely applied in studies of PI3K/Akt signaling cancer progression and therapeutic response
Medchemexpress LLC Impdh-in-3 | 401822-29-5 | 90.0% | 10 MG
IMPDH-IN-3 (Compound C67) is an inhibitor of *C. parvum* IMPDH (CpIMPDH) with an IC50 of 35 nM. It can be used in the research of anti-Cryptosporidium drugs.
- Inhibits C. parvum IMPDH
- Has an IC50 of 35 nM
- Useful in the research of anti-Cryptosporidium drugs
Cayman Chemical JX06, Purity: ≥98%, CAS: 729-46-4, 10 mg
An irreversible PDHK inhibitor (IC50s = 49, 101, and 313 nM for PDHK1, PDHK2, and PDHK3, respectively); selective for PDHK1-3 over PDHK4 (IC50 = >10 µM) and 322 other kinases at 10 µM but does inhibit FAK in a cell-free assay but not in a cell-based assay; increases ROS production and induces apoptosis in cancer cells with a high ECAR:OCR ratio; reduces the level of glycolysis metabolites in NCI H929 multiple myeloma cells at 0.25 µM; reduces tumor growth in an A549 mouse xenograft model
Cayman Chemical 1,2-Dipalmitoyl-3-Myristoyl-rac-glycerol, Purity: ≥98%, CAS: 60138-14-9, 5 mg
A triacylglycerol; has been found in bovine milk fat
Cayman Chemical Estropipate, Purity: ≥98%, CAS: 7280-37-7, 5 mg
A piperazine salt form of estrone 3-sulfate; inhibits OATP1B1 selectively over OATP1B3 (IC50s = 0.06 and 19.32 µM, respectively)
Medchemexpress LLC GNE 5729 | 2026635-66-3 | MFCD30829916 | 99.1% | 428.20 g·mol⁻¹ | C17H10Cl2F3N5O | 50 MG
GNE 5729 is a brain-permeable positive allosteric modulator of the N-methyl-D-aspartate receptor (NMDAR) used for biochemical and pharmacological research. It displays subtype-selective activity and physicochemical properties suitable for in vitro and in vivo studies.
- Brain-permeable positive allosteric modulator of NMDAR.
- Potent activity at GluN2A (EC50 37 nM); micromolar activity at GluN2C and GluN2D.
- High purity reported at 99.05%.
- Molecular weight 428.20 g·mol⁻¹ and formula C17H10Cl2F3N5O.
- Soluble in DMSO for experimental preparations.
- Available in small research quantities such as 50 MG.
Medchemexpress LLC (Z)-3-propyl-2-(o-tolylimino)thiazolidin-4-one | 1228116-62-8 | MFCD31560466 | 50mg
(Z)-3-propyl-2-(o-tolylimino)thiazolidin-4-one is a drug impurity